|Application ||WB, E|
|Other Accession||NP_542179.1, NP_001075042.1|
|Calculated MW||65589 Da|
|Antigen Region||30-58 aa|
|Other Names||GRB2-associated-binding protein 3, GRB2-associated binder 3, Growth factor receptor bound protein 2-associated protein 3, GAB3|
|Target/Specificity||This GAB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 30-58 amino acids from the N-terminal region of human GAB3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GAB3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
GAB3 is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Two transcript variants encoding different isoforms have been found for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Barrett, J.C., et al. Nat. Genet. 41(6):703-707(2009)
Seiffert, M., et al. Mol. Cell. Biol. 23(7):2415-2424(2003)
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