|Application ||WB, E|
|Calculated MW||71992 Da|
|Antigen Region||79-108 aa|
|Other Names||Sodium/potassium/calcium exchanger 3, Na(+)/K(+)/Ca(2+)-exchange protein 3, Solute carrier family 24 member 3, SLC24A3, NCKX3|
|Target/Specificity||This SLC24A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-108 amino acids from the N-terminal region of human SLC24A3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SLC24A3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+).|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Abundant in the brain. Expressed at low levels in the aorta, uterus and intestine|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions (Kraev et al., 2001 [PubMed 11294880]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Cheng, Y.C., et al. Circ Cardiovasc Genet 2(4):329-337(2009)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Kraev, A., et al. J. Biol. Chem. 276(25):23161-23172(2001)
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