SLC24A3 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q9HC58 |
Other Accession | NP_065740.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 71992 Da |
Antigen Region | 79-108 aa |
Gene ID | 57419 |
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Other Names | Sodium/potassium/calcium exchanger 3, Na(+)/K(+)/Ca(2+)-exchange protein 3, Solute carrier family 24 member 3, SLC24A3, NCKX3 |
Target/Specificity | This SLC24A3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 79-108 amino acids from the N-terminal region of human SLC24A3. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SLC24A3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLC24A3 |
---|---|
Synonyms | NCKX3 {ECO:0000303|PubMed:26631410} |
Function | Calcium, potassium:sodium antiporter that transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Abundant in the brain (PubMed:11294880). Expressed at low levels in the aorta, uterus and intestine (PubMed:11294880) |
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Provided below are standard protocols that you may find useful for product applications.
Background
Plasma membrane sodium/calcium exchangers are an important component of intracellular calcium homeostasis and electrical conduction. Potassium-dependent sodium/calcium exchangers such as SLC24A3 are believed to transport 1 intracellular calcium and 1 potassium ion in exchange for 4 extracellular sodium ions (Kraev et al., 2001 [PubMed 11294880]).
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Cheng, Y.C., et al. Circ Cardiovasc Genet 2(4):329-337(2009)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Kraev, A., et al. J. Biol. Chem. 276(25):23161-23172(2001)
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