|Application ||WB, E|
|Other Accession||Q02788, NP_001840.3, NP_478055.2|
|Calculated MW||108579 Da|
|Antigen Region||719-747 aa|
|Other Names||Collagen alpha-2(VI) chain, COL6A2|
|Target/Specificity||This COL6A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 719-747 amino acids from the C-terminal region of human COL6A2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COL6A2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Collagen VI acts as a cell-binding protein.|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Membrane; Peripheral membrane protein. Note=Recruited on membranes by CSPG4|
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Provided below are standard protocols that you may find useful for product applications.
COL6A2 is one of the three alpha chains of type VI collagen, a beaded filament collagen found in most connective tissues. The product of this gene contains several domains similar to von Willebrand Factor type A domains. These domains have been shown to bind extracellular matrix proteins, an interaction that explains the importance of this collagen in organizing matrix components. Mutations in this gene are associated with Bethlem myopathy and Ullrich scleroatonic muscular dystrophy. Three transcript variants have been identified for this gene. [provided by RefSeq].
Zhang, R.Z., et al. J. Biol. Chem. 285(13):10005-10015(2010)
Bovolenta, M., et al. BMC Med. Genet. 11, 44 (2010) :
Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009)
Freise, C., et al. Matrix Biol. 28(8):480-489(2009)
Martoni, E., et al. Hum. Mutat. 30 (5), E662-E672 (2009) :
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