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CD226 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CD226 Antibody (C-term) AP16399B
    CD226 Antibody (C-term) (Cat. #AP16399b) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the CD226 antibody detected the CD226 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q15762
Other Accession NP_006557.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 38614 Da
Antigen Region 307-335 aa
Additional Information
Gene ID 10666
Other Names CD226 antigen, DNAX accessory molecule 1, DNAM-1, CD226, CD226, DNAM1
Target/Specificity This CD226 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-335 amino acids from the C-terminal region of human CD226.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCD226 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CD226
Synonyms DNAM1
Function Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T- lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705).
Cellular Location Cell membrane; Single-pass type I membrane protein
Tissue Location Expressed by peripheral blood T-lymphocytes.
Research Areas
Citations (0)
citation

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Background

CD226 is a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq].

References

Lofgren, S.E., et al. Arthritis Rheum. 62(11):3404-3414(2010)
Carlsten, M., et al. Leukemia 24(9):1607-1616(2010)
Plant, D., et al. Ann. Rheum. Dis. 69(8):1548-1553(2010)
Alcina, A., et al. Genes Immun. 11(5):439-445(2010)
Jian, J.L., et al. J. Biol. Chem. 281(39):28731-28736(2006)

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$ 182.50
$ 70.00
Cat# AP16399B
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