CD226 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q15762 |
Other Accession | NP_006557.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 38614 Da |
Antigen Region | 307-335 aa |
Gene ID | 10666 |
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Other Names | CD226 antigen, DNAX accessory molecule 1, DNAM-1, CD226, CD226, DNAM1 |
Target/Specificity | This CD226 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-335 amino acids from the C-terminal region of human CD226. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CD226 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CD226 |
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Synonyms | DNAM1 |
Function | Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T- lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705). |
Cellular Location | Cell membrane; Single-pass type I membrane protein |
Tissue Location | Expressed by peripheral blood T-lymphocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CD226 is a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq].
References
Lofgren, S.E., et al. Arthritis Rheum. 62(11):3404-3414(2010)
Carlsten, M., et al. Leukemia 24(9):1607-1616(2010)
Plant, D., et al. Ann. Rheum. Dis. 69(8):1548-1553(2010)
Alcina, A., et al. Genes Immun. 11(5):439-445(2010)
Jian, J.L., et al. J. Biol. Chem. 281(39):28731-28736(2006)
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