|Application ||WB, E|
|Calculated MW||38614 Da|
|Antigen Region||307-335 aa|
|Other Names||CD226 antigen, DNAX accessory molecule 1, DNAM-1, CD226, CD226, DNAM1|
|Target/Specificity||This CD226 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-335 amino acids from the C-terminal region of human CD226.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD226 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T- cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed by peripheral blood T-lymphocytes.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
CD226 is a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq].
Lofgren, S.E., et al. Arthritis Rheum. 62(11):3404-3414(2010)
Carlsten, M., et al. Leukemia 24(9):1607-1616(2010)
Plant, D., et al. Ann. Rheum. Dis. 69(8):1548-1553(2010)
Alcina, A., et al. Genes Immun. 11(5):439-445(2010)
Jian, J.L., et al. J. Biol. Chem. 281(39):28731-28736(2006)
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