|Application ||WB, E|
|Calculated MW||38614 Da|
|Antigen Region||307-335 aa|
|Other Names||CD226 antigen, DNAX accessory molecule 1, DNAM-1, CD226, CD226, DNAM1|
|Target/Specificity||This CD226 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-335 amino acids from the C-terminal region of human CD226.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD226 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704). Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T- cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705).|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Expressed by peripheral blood T-lymphocytes.|
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Provided below are standard protocols that you may find useful for product applications.
CD226 is a glycoprotein expressed on the surface of NK cells, platelets, monocytes and a subset of T cells. It is a member of the Ig-superfamily containing 2 Ig-like domains of the V-set. The protein mediates cellular adhesion of platelets and megakaryocytic cells to vascular endothelial cells. The protein also plays a role in megakaryocytic cell maturation. [provided by RefSeq].
Lofgren, S.E., et al. Arthritis Rheum. 62(11):3404-3414(2010)
Carlsten, M., et al. Leukemia 24(9):1607-1616(2010)
Plant, D., et al. Ann. Rheum. Dis. 69(8):1548-1553(2010)
Alcina, A., et al. Genes Immun. 11(5):439-445(2010)
Jian, J.L., et al. J. Biol. Chem. 281(39):28731-28736(2006)
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