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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   GUCA2B Antibody (C-term)   

GUCA2B Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - GUCA2B Antibody (C-term) AP16404b
    GUCA2B Antibody (C-term) (Cat. #AP16404b) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the GUCA2B antibody detected the GUCA2B protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q16661
Other Accession NP_009033.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 12069 Da
Antigen Region 69-97 aa
Additional Information
Gene ID 2981
Other Names Guanylate cyclase activator 2B, Guanylate cyclase C-activating peptide 2, Guanylate cyclase C-activating peptide II, GCAP-II, Uroguanylin, UGN, GUCA2B
Target/Specificity This GUCA2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-97 amino acids from the C-terminal region of human GUCA2B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsGUCA2B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins. May be a potent physiological regulator of intestinal fluid and electrolyte transport. May be an autocrine/paracrine regulator of intestinal salt and water transport.
Cellular Location Secreted.
Tissue Location Stomach and intestine.
Research Areas
Citations (0)

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Uroguanylin and guanylin (GUCA2A; MIM 139392), peptide homologs of the bacterial heat-stable enterotoxins (e.g., the E. coli ST toxin; STa), are endogenous activators of the guanylate cyclase-2C receptor (GUCY2C; MIM 601330), which synthesizes cyclic GMP (cGMP), a key component of several intracellular signal transduction pathways.


Yoshikawa, Y., et al. Hypertens. Res. 30(9):789-796(2007)
Guo, H.F., et al. Zhonghua Xin Xue Guan Bing Za Zhi 35(3):233-236(2007)
Sindic, A., et al. Kidney Int. 67(4):1420-1427(2005)
Maake, C., et al. Histochem. Cell Biol. 119(1):69-76(2003)
Sindice, A., et al. J. Biol. Chem. 277(20):17758-17764(2002)

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$ 295.00
$ 99.00
Cat# AP16404b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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