|Application ||WB, E|
|Calculated MW||102281 Da|
|Antigen Region||644-673 aa|
|Other Names||Kinesin-like protein KIF18A, Marrow stromal KIF18A, MS-KIF18A, KIF18A|
|Target/Specificity||This KIF18A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 644-673 amino acids from the C-terminal region of human KIF18A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KIF18A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.|
|Cellular Location||Cell projection, ruffle. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome|
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Provided below are standard protocols that you may find useful for product applications.
KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM].
Zhang, C., et al. Carcinogenesis 31(9):1676-1684(2010)
Du, Y., et al. Curr. Biol. 20(4):374-380(2010)
Huang, Y., et al. Cell Cycle 8(16):2643-2649(2009)
Zusev, M., et al. J. Cell. Physiol. 217(3):618-625(2008)
Stumpff, J., et al. Dev. Cell 14(2):252-262(2008)
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