|Application ||WB, E|
|Calculated MW||102281 Da|
|Antigen Region||644-673 aa|
|Other Names||Kinesin-like protein KIF18A, Marrow stromal KIF18A, MS-KIF18A, KIF18A|
|Target/Specificity||This KIF18A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 644-673 amino acids from the C-terminal region of human KIF18A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||KIF18A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Microtubule-depolymerizing kinesin which plays a role in chromosome congression by reducing the amplitude of preanaphase oscillations and slowing poleward movement during anaphase, thus suppressing chromosome movements. May stabilize the CENPE-BUB1B complex at the kinetochores during early mitosis and maintains CENPE levels at kinetochores during chromosome congression.|
|Cellular Location||Cell projection, ruffle. Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM].
Zhang, C., et al. Carcinogenesis 31(9):1676-1684(2010)
Du, Y., et al. Curr. Biol. 20(4):374-380(2010)
Huang, Y., et al. Cell Cycle 8(16):2643-2649(2009)
Zusev, M., et al. J. Cell. Physiol. 217(3):618-625(2008)
Stumpff, J., et al. Dev. Cell 14(2):252-262(2008)
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