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>   home   >   Products   >   Primary Antibodies   >   Antibody Collections   >   GPCR Antibodies   >   Metabotropic Glutamate Receptor 7 (GPRC1G) Antibody (C-term)   

Metabotropic Glutamate Receptor 7 (GPRC1G) Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - Metabotropic Glutamate Receptor 7 (GPRC1G) Antibody (C-term) AP1640a
    Anti-GPRC1G Antibody (C-term) at 1:1000 dilution + SH-SY5Y whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 102 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
  • IHC-P - Metabotropic Glutamate Receptor 7 (GPRC1G) Antibody (C-term) AP1640a
    Metabotropic Glutamate Receptor 7 (GPRC1G) Antibody (C-term) (Cat. #AP1640a)immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Metabotropic Glutamate Receptor 7 (GPRC1G) Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q14831
Other Accession P35400, Q68ED2, NP_870989
Reactivity Human
Predicted Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 102251 Da
Antigen Region 857-887 aa
Additional Information
Gene ID 2917
Other Names Metabotropic glutamate receptor 7, mGluR7, GRM7, GPRC1G, MGLUR7
Target/Specificity This Metabotropic Glutamate Receptor 7 (GPRC1G) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 857-887 amino acids from the C-terminal region of human Metabotropic Glutamate Receptor 7 (GPRC1G).
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMetabotropic Glutamate Receptor 7 (GPRC1G) Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name GRM7
Synonyms GPRC1G, MGLUR7
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Cellular Location Cell membrane; Multi-pass membrane protein.
Tissue Location Expressed in many areas of the brain, especially in the cerebral cortex, hippocampus, and cerebellum Expression of GRM7 isoforms in non-neuronal tissues appears to be restricted to isoform 3 and isoform 4
Research Areas
Citations (0)

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L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.


Schulz, H.L., et al., Neurosci. Lett. 326(1):37-40 (2002).
Flor, P.J., et al., Neuropharmacology 36(2):153-159 (1997).
Makoff, A., et al., Brain Res. Mol. Brain Res. 40(1):165-170 (1996).
Scherer, S.W., et al., Genomics 31(2):230-233 (1996).
Okamoto, N., et al., J. Biol. Chem. 269(2):1231-1236 (1994).

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$ 295.00
$ 99.00
Cat# AP1640a
(40 western blots)
Availability: In Stock
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