|Application ||WB, E|
|Other Accession||Q99P39, Q9Z1J3, NP_066923.3|
|Calculated MW||50196 Da|
|Antigen Region||121-149 aa|
|Other Names||Cysteine desulfurase, mitochondrial, NFS1, NIFS|
|Target/Specificity||This NFS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 121-149 amino acids from the Central region of human NFS1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NFS1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron- sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor.|
|Cellular Location||Isoform Mitochondrial: Mitochondrion.|
|Tissue Location||Predominantly expressed in heart and skeletal muscle. Also found in brain, liver and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
Iron-sulfur clusters are required for the function of many cellular enzymes. The proteins encoded by this gene supply inorganic sulfur to these clusters by removing the sulfur from cysteine, creating alanine in the process. This gene uses alternate in-frame translation initiation sites to generate mitochondrial forms and cytoplasmic/nuclear forms. Selection of the alternative initiation sites is determined by the cytosolic pH. The encoded proteins belong to the class-V family of pyridoxal phosphate-dependent aminotransferases. Alternatively spliced transcript variants have been described.
Naamati, A., et al. J. Biol. Chem. 284(44):30200-30208(2009)
Marelja, Z., et al. J. Biol. Chem. 283(37):25178-25185(2008)
Wu, C., et al. Proteomics 7(11):1775-1785(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Biederbick, A., et al. Mol. Cell. Biol. 26(15):5675-5687(2006)
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