|Application ||WB, E|
|Calculated MW||91982 Da|
|Antigen Region||37-65 aa|
|Other Names||Polycystic kidney disease 2-like 1 protein, Polycystin-2 homolog, Polycystin-2L1, Polycystin-L, Polycystin-L1, PKD2L1, PKD2L, PKDL, TRPP3|
|Target/Specificity||This PKD2L1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 37-65 amino acids from the N-terminal region of human PKD2L1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PKD2L1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||PKD2L, PKDL, TRPP3|
|Function||Pore-forming subunit of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD1L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. May act as a sour taste receptor by forming a calcium channel with PKD1L3 in gustatory cells; however, its contribution to sour taste perception is unclear in vivo and may be indirect.|
|Cellular Location||Cell projection, cilium membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein Endoplasmic reticulum. Note=Interaction with PKD1 or PKD1L3 is required for localization to the cell membrane|
|Tissue Location||Expressed in adult heart, skeletal muscle, brain, spleen, testis, retina and liver. According to PubMed:9748274, expressed at high levels in fetal tissues, including kidney and liver, and down-regulated in adult tissues According to PubMed:10602361, expressed in fetal brain, but not expressed in fetal lung, liver or kidney. Isoform 4 appears to be expressed only in transformed lymphoblasts|
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Provided below are standard protocols that you may find useful for product applications.
PKD2L1 is a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. This protein functions as a calcium-regulated nonselective cation channel. Alternative splice variants have been described but their full length sequences have not been determined.
Molland, K.L., et al. Biochem. J. 429(1):171-183(2010)
Kawaguchi, H., et al. J. Biol. Chem. 285(23):17277-17281(2010)
Li, Q., et al. J. Neurochem. 103(6):2391-2400(2007)
Geng, L., et al. J. Cell. Sci. 119 (PT 7), 1383-1395 (2006) :
Grupe, A., et al. Am. J. Hum. Genet. 78(1):78-88(2006)
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