|Application ||WB, E|
|Calculated MW||100984 Da|
|Antigen Region||561-590 aa|
|Other Names||Chromodomain-helicase-DNA-binding protein 1-like, Amplified in liver cancer protein 1, CHD1L, ALC1|
|Target/Specificity||This CHD1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 561-590 amino acids from the Central region of human CHD1L.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Precautions||CHD1L Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||DNA helicase which plays a role in chromatin-remodeling following DNA damage. Targeted to sites of DNA damage through interaction with poly(ADP-ribose) and functions to regulate chromatin during DNA repair. Able to catalyze nucleosome sliding in an ATP-dependent manner. Helicase activity is strongly stimulated upon poly(ADP-ribose)-binding.|
|Cellular Location||Nucleus. Note=Localizes at sites of DNA damage. Probably recruited to DNA damage sites by PARylated PARP1|
|Tissue Location||Frequently overexpressed in hepatomacellular carcinomas.|
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Provided below are standard protocols that you may find useful for product applications.
In response to DNA strand breaks, chromatin adopts a relaxed structure due to the addition of poly(ADP-ribose) (PAR) to chromatin proteins by PARP enzymes (see PARP1; MIM 173870), and this relaxation facilitates the repair of DNA damage. CHD1L interacts with PAR and has a role in chromatin relaxation following DNA damage (Ahel et al., 2009 [PubMed 19661379]).[supplied by OMIM].
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Chen, L., et al. J. Clin. Invest. 120(4):1178-1191(2010)
Ahel, D., et al. Science 325(5945):1240-1243(2009)
Gottschalk, A.J., et al. Proc. Natl. Acad. Sci. U.S.A. 106(33):13770-13774(2009)
Melzer, D., et al. PLoS Genet. 4 (5), E1000072 (2008) :
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