|Application ||WB, E|
|Calculated MW||107473 Da|
|Antigen Region||529-558 aa|
|Other Names||Scaffold attachment factor B2, SAF-B2, SAFB2, KIAA0138|
|Target/Specificity||This SAFB2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 529-558 amino acids from the Central region of human SAFB2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SAFB2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.|
|Cellular Location||Cytoplasm. Nucleus.|
|Tissue Location||Expressed at high levels in the CNS and at low levels in the liver. Expressed in a wide number of breast cancer cell lines|
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Provided below are standard protocols that you may find useful for product applications.
SAFB2 binds to scaffold/matrix attachment region (S/MAR) DNA. Can function as an estrogen receptor corepressor and can also inhibit cell proliferation.
Hammerich-Hille, S., et al. Breast Cancer Res. Treat. 121(2):503-509(2010)
Hammerich-Hille, S., et al. J. Biol. Chem. 285(6):3608-3616(2010)
Tsianou, D., et al. FEBS J. 276(18):5212-5227(2009)
Bergman, A., et al. BMC Med. Genet. 9, 108 (2008) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
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