|Application ||WB, E|
|Other Accession||NP_001119595.1, NP_974487.1, NP_059982.2|
|Calculated MW||49786 Da|
|Antigen Region||63-92 aa|
|Other Names||Mitochondrial enolase superfamily member 1, Antisense RNA to thymidylate synthase, rTS, L-fuconate dehydratase, ENOSF1, RTS, TYMSAS|
|Target/Specificity||This ENOSF1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-92 amino acids from the N-terminal region of human ENOSF1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ENOSF1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in the catabolism of L-fucose, a sugar that is part of the carbohydrates that are attached to cellular glycoproteins. Catalyzes the dehydration of L-fuconate to 2-keto- 3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion (PubMed:24697329).|
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Provided below are standard protocols that you may find useful for product applications.
ENOSF1 was originally identified as a naturally occurring antisense transcript to the human thymidylate synthase gene. Alternate splice variants have been described, one of which (named rTSalpha) represents an alternate 3'UTR that is complementary to the 3'UTR and terminal intron of the thymidylate synthase (TS) RNA and down-regulates TS expression. Other transcript variants (rTSbeta and rTSgamma) do not overlap the TS locus. The function of this gene appears to be primarily to regulate expression of the TS locus both via the antisense transcript as well as through the encoded proteins. [provided by RefSeq].
Giusti, B., et al. Thromb. Haemost. 104(2):231-242(2010)
Wang, Y., et al. J. Hum. Genet. 55(8):490-494(2010)
Cross, D.S., et al. BMC Genet. 11, 51 (2010) :
Giusti, B., et al. J. Med. Genet. 45(11):721-730(2008)
Giusti, B., et al. Biochem. Genet. 46 (7-8), 406-423 (2008) :
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