|Application ||WB, E|
|Calculated MW||35556 Da|
|Antigen Region||278-307 aa|
|Other Names||snRNA-activating protein complex subunit 2, SNAPc subunit 2, Proximal sequence element-binding transcription factor subunit delta, PSE-binding factor subunit delta, PTF subunit delta, Small nuclear RNA-activating complex polypeptide 2, snRNA-activating protein complex 45 kDa subunit, SNAPc 45 kDa subunit, SNAPC2, SNAP45|
|Target/Specificity||This SNAPC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 278-307 amino acids from the C-terminal region of human SNAPC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SNAPC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.|
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Provided below are standard protocols that you may find useful for product applications.
SNAPC2 is a subunit of the snRNA-activating protein complex which is associated with the TATA box-binding protein. The encoded protein is necessary for RNA polymerase II and III dependent small-nuclear RNA gene transcription. Alternative splicing results in multiple transcript variants. [provided by RefSeq].
Shanmugam, M., et al. J. Biol. Chem. 283(21):14845-14856(2008)
Emran, F., et al. Gene 377, 96-108 (2006) :
Hinkley, C.S., et al. J. Biol. Chem. 278(20):18649-18657(2003)
Acierno, J.S. Jr., et al. Genomics 73(2):203-210(2001)
Ma, B., et al. J. Biol. Chem. 276(7):5027-5035(2001)
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