|Application ||WB, E|
|Calculated MW||52963 Da|
|Antigen Region||96-125 aa|
|Other Names||Zinc finger and BTB domain-containing protein 32, FANCC-interacting protein, Fanconi anemia zinc finger protein, Testis zinc finger protein, Zinc finger protein 538, ZBTB32, FAZF, TZFP, ZNF538|
|Target/Specificity||This ZBTB32 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-125 amino acids from the N-terminal region of human ZBTB32.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZBTB32 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||FAZF, TZFP, ZNF538|
|Function||DNA-binding protein that binds to the to a 5'- TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).|
|Cellular Location||Nucleus. Note=Located in nuclear speckles|
|Tissue Location||Predominantly expressed in testis. Some isoforms are ubiquitously expressed|
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Provided below are standard protocols that you may find useful for product applications.
ZBTB32 is a DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T cells (By similarity).
Stogios, P.J., et al. J. Mol. Biol. 400(5):983-997(2010)
Kaufmann, S., et al. J. Gen. Virol. 91 (PT 6), 1494-1502 (2010) :
Xin, X., et al. Genome Res. 19(7):1262-1269(2009)
Cohn, M.A., et al. Mol. Cell 28(5):786-797(2007)
Ikeda, R., et al. J. Cell. Biochem. 101(1):147-154(2007)
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