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SNAPC1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SNAPC1 Antibody (Center) AP16433c
    SNAPC1 Antibody (Center) (Cat. #AP16433c) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the SNAPC1 antibody detected the SNAPC1 protein (arrow).
  • WB - SNAPC1 Antibody (Center) AP16433c
    Western blot analysis of SNAPC1 (arrow) using rabbit polyclonal SNAPC1 Antibody (Center) (Cat. #AP16433c). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SNAPC1 gene.
  • SPECIFICATION
  • CITATIONS
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q16533
Other Accession Q4R6W9, NP_003073.1
Reactivity Human
Predicted Monkey
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Antigen Region 139-168 aa
Additional Information
Other Names snRNA-activating protein complex subunit 1, SNAPc subunit 1, Proximal sequence element-binding transcription factor subunit gamma, PSE-binding factor subunit gamma, PTF subunit gamma, Small nuclear RNA-activating complex polypeptide 1, snRNA-activating protein complex 43 kDa subunit, SNAPc 43 kDa subunit, SNAPC1, SNAP43
Target/Specificity This SNAPC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 139-168 amino acids from the Central region of human SNAPC1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSNAPC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SNAPC1
Synonyms SNAP43
Function Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.
Cellular Location Nucleus. EMBL; Z47542; CAA87590.1; -; mRNA EMBL; U44754; AAC50358.1; -; mRNA EMBL; BC014984; AAH14984.1; -; mRNA EMBL; BC019038; AAH19038.1; -; mRNA CCDS; CCDS9755.1; - PIR; JC6081; JC6081 RefSeq; NP_003073.1; NM_003082.3 UniGene; Hs.179312; - ProteinModelPortal; Q16533; - BioGrid; 112501; 13 DIP; DIP-504N; - IntAct; Q16533; 1 STRING; 9606.ENSP00000216294; - iPTMnet; Q16533; - PhosphoSitePlus; Q16533; - BioMuta; SNAPC1; - DMDM; 8134716; - EPD; Q16533; - MaxQB; Q16533; - PaxDb; Q16533; - PeptideAtlas; Q16533; - PRIDE; Q16533; - DNASU; 6617; - Ensembl; ENST00000216294; ENSP00000216294; ENSG00000023608 GeneID; 6617; - KEGG; hsa:6617; - UCSC; uc001xft.3; human CTD; 6617; - DisGeNET; 6617; - GeneCards; SNAPC1; - HGNC; HGNC:11134; SNAPC1 HPA; HPA059014; - MIM; 600591; gene neXtProt; NX_Q16533; - OpenTargets; ENSG00000023608; - PharmGKB; PA35982; - eggNOG; KOG4746; Eukaryota eggNOG; ENOG410Z6WG; LUCA GeneTree; ENSGT00390000018691; - HOGENOM; HOG000294209; - HOVERGEN; HBG058831; - InParanoid; Q16533; - KO; K15208; - OMA; NMFTKEA; - OrthoDB; EOG091G0R68; - PhylomeDB; Q16533; - TreeFam; TF324445; - BioCyc; ZFISH:ENSG00000023608-MONOMER; - Reactome; R-HSA-6807505; RNA polymerase II transcribes snRNA genes Reactome; R-HSA-749476; RNA Polymerase III Abortive And Retractive Initiation Reactome; R-HSA-76071; RNA Polymerase III Transcription Initiation From Type 3 Promoter ChiTaRS; SNAPC1; human GeneWiki; SNAPC1; - GenomeRNAi; 6617; - PRO; PR:Q16533; - Proteomes; UP000005640; Chromosome 14 Bgee; ENSG00000023608; - CleanEx; HS_SNAPC1; - Genevisible; Q16533; HS GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA GO; GO:0005730; C:nucleolus; IDA:HPA GO; GO:0005654; C:nucleoplasm; TAS:Reactome GO; GO:0005634; C:nucleus; IDA:HPA GO; GO:0019185; C:snRNA-activating protein complex; IBA:GO_Central GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-KW GO; GO:0042795; P:snRNA transcription from RNA polymerase II promoter; IBA:GO_Central GO; GO:0042796; P:snRNA transcription from RNA polymerase III promoter; IBA:GO_Central InterPro; IPR019188; SNAPc_SNAP43 PANTHER; PTHR15131; PTHR15131; 1 Pfam; PF09808; SNAPc_SNAP43; 1 1: Evidence at protein level; Complete proteome; Direct protein sequencing; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation CHAIN 1 368 snRNA-activating protein complex subunit 1 /FTId=PRO_0000072017 REGION 1 168 SNAPC3-binding REGION 164 268 SNAPC4-binding COMPBIAS 347 352 Poly-Glu MOD_RES 289 289 Phosphoserine MOD_RES 290 290 Phosphoserine SEQUENCE 368 AA; 42994 MW; 324E89CF8B540C32 CRC64; MGTPPGLQTD CEALLSRFQE TDSVRFEDFT ELWRNMKFGT IFCGRMRNLE KNMFTKEALA LAWRYFLPPY TFQIRVGALY LLYGLYNTQL CQPKQKIRVA LKDWDEVLKF QQDLVNAQHF DAAYIFRKLR LDRAFHFTAM PKLLSYRMKK KIHRAEVTEE FKDPSDRVMK LITSDVLEEM LNVHDHYQNM KHVISVDKSK PDKALSLIKD DFFDNIKNIV LEHQQWHKDR KNPSLKSKTN DGEEKMEGNS QETERCERAE SLAKIKSKAF SVVIQASKSR RHRQVKLDSS DSDSASGQGQ VKATRKKEKK ERLKPAGRKM SLRNKGNVQN IHKEDKPLSL SMPVITEEEE NESLSGTEFT ASKKRRKH
Citations (0)

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Background

Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box.

References

Gu, L., et al. J. Biol. Chem. 280(30):27697-27704(2005)
Hinkley, C.S., et al. J. Biol. Chem. 278(20):18649-18657(2003)
Ma, B., et al. J. Biol. Chem. 276(7):5027-5035(2001)
Hirsch, H.A., et al. Mol. Cell. Biol. 20(24):9182-9191(2000)
Maeng, J.H., et al. J. Biochem. 124(1):23-27(1998)

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$ 295.00
$ 99.00
Cat# AP16433c
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(40 western blots)
Availability: In Stock
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