|Application ||WB, E|
|Calculated MW||19024 Da|
|Antigen Region||1-30 aa|
|Other Names||M-phase phosphoprotein 6, MPHOSPH6, MPP6|
|Target/Specificity||This MPHOSPH6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human MPHOSPH6.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MPHOSPH6 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and may play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D.|
|Cellular Location||Nucleus, nucleolus. Cytoplasm. Note=Cytoplasmic in M phase|
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Provided below are standard protocols that you may find useful for product applications.
Progression of cells from interphase to mitosis involves alterations in cell structures and activities. The transition from G2 to M phase is induced by M phase promoting factor, or MPF. In M phase, many proteins are phosphorylated directly by MPF or indirectly by kinases activated by MPF. These M phase phosphoproteins (MPPs, or MPHOSPHs) permit disassembly of interphase structures and generation of M phase enzymatic activities and structures.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Need, A.C., et al. Hum. Mol. Genet. 18(23):4650-4661(2009)
Org, E., et al. Hum. Mol. Genet. 18(12):2288-2296(2009)
Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
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