|Application ||WB, E|
|Other Accession||NP_001093869.1, NP_001093870.1|
|Calculated MW||150830 Da|
|Antigen Region||1309-1337 aa|
|Other Names||Sister chromatid cohesion protein PDS5 homolog A, Cell proliferation-inducing gene 54 protein, Sister chromatid cohesion protein 112, SCC-112, PDS5A (HGNC:29088)|
|Target/Specificity||This PDS5A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1309-1337 amino acids from the C-terminal region of human PDS5A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PDS5A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Probable regulator of sister chromatid cohesion in mitosis which may stabilize cohesin complex association with chromatin. May couple sister chromatid cohesion during mitosis to DNA replication. Cohesion ensures that chromosome partitioning is accurate in both meiotic and mitotic cells and plays an important role in DNA repair.|
|Cellular Location||Nucleus. Note=Associated with chromatin through most of the cell cycle. Dissociates from chromatin in late prophase, reassociates during late telophase|
|Tissue Location||Highest level in colon. Low levels in lung, ovary, breast and kidney. Reduced level in renal tumor tissue Isoform 2 is expressed in kidney.|
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PDS5A may contribute to regulation of sister chromatid cohesion during mitosis.
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