|Application ||WB, E|
|Other Accession||O88626, O88853, NP_003605.1|
|Calculated MW||39573 Da|
|Antigen Region||279-307 aa|
|Other Names||Galanin receptor type 3, GAL3-R, GALR-3, GALR3, GALNR3|
|Target/Specificity||This GALR3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 279-307 amino acids from the C-terminal region of human GALR3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GALR3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor for the hormone galanin. Receptor for the hormone spexin-1 (PubMed:24517231).|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
The neuropeptide galanin modulates a variety of physiologic processes including cognition/memory, sensory/pain processing, hormone secretion, and feeding behavior. The human galanin receptors are G protein-coupled receptors that functionally couple to their intracellular effector through distinct signaling pathways. GALR3 is found in many tissues and may be expressed as 1.4-, 2.4-, and 5-kb transcripts
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)
Gratacos, M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6), 808-816 (2009) :
Belfer, I., et al. Genes Brain Behav. 6(5):473-481(2007)
Berger, A., et al. Neuroendocrinology 75(2):130-138(2002)
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