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DTX3L Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - DTX3L Antibody (Center) AP16451c
    DTX3L Antibody (Center) (Cat. #AP16451c) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the DTX3L antibody detected the DTX3L protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8TDB6
Other Accession NP_612144.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 83554 Da
Antigen Region 453-482 aa
Additional Information
Gene ID 151636
Other Names E3 ubiquitin-protein ligase DTX3L, 632-, B-lymphoma- and BAL-associated protein, Protein deltex-3-like, Rhysin-2, Rhysin2, DTX3L, BBAP
Target/Specificity This DTX3L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453-482 amino acids from the Central region of human DTX3L.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDTX3L Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DTX3L
Synonyms BBAP
Function Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1- dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.
Cellular Location Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage in a PARP1-dependent manner
Citations (0)

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DTX3L functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).


Yan, Q., et al. Mol. Cell 36(1):110-120(2009)
Wilting, S.M., et al. Genes Chromosomes Cancer 47(10):890-905(2008)
Juszczynski, P., et al. Mol. Cell. Biol. 26(14):5348-5359(2006)
Takeyama, K., et al. J. Biol. Chem. 278(24):21930-21937(2003)

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$ 295.00
$ 99.00
Cat# AP16451c
(40 western blots)
Availability: In Stock
Bulk Size
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