|Application ||WB, E|
|Calculated MW||39031 Da|
|Antigen Region||296-325 aa|
|Other Names||LIM and senescent cell antigen-like-containing domain protein 2, Particularly interesting new Cys-His protein 2, PINCH-2, Lims2, Pinch2|
|Target/Specificity||This Mouse Lims2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-325 amino acids from the C-terminal region of mouse Lims2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Lims2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Adapter protein in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.|
|Cellular Location||Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side|
|Tissue Location||Detected in heart, lung, kidney, liver, urinary bladder, fat, skin, skeletal muscle, uterus, large intestine and testis.|
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Provided below are standard protocols that you may find useful for product applications.
Competes with LIMS1 for binding to ILK. Plays a role in modulating cell spreading and migration (By similarity).
Guo, G., et al. Dev. Cell 18(4):675-685(2010)
Liang, X., et al. Circulation 120(7):568-576(2009)
Pereira, J.A., et al. J. Cell Biol. 185(1):147-161(2009)
Aguado, T., et al. J. Neurosci. 26(5):1551-1561(2006)
Stanchi, F., et al. J. Cell. Sci. 118 (PT 24), 5899-5910 (2005) :
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