|Application ||WB, E|
|Calculated MW||25000 Da|
|Antigen Region||19-45 aa|
|Other Names||Growth hormone variant, GH-V, Growth hormone 2, Placenta-specific growth hormone, GH2|
|Target/Specificity||This GH2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 19-45 amino acids from the N-terminal region of human GH2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GH2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.|
|Tissue Location||Expressed in the placenta.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones which play an important role in growth control. The gene, along with four other related genes, is located at the growth hormone locus on chromosome 17 where they are interspersed in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. The five genes share a remarkably high degree of sequence identity. Alternative splicing generates additional isoforms of each of the five growth hormones, leading to further diversity and potential for specialization. As in the case of its pituitary counterpart, growth hormone 1, the predominant isoform of this particular family member shows similar somatogenic activity, with reduced lactogenic activity. Mutations in this gene lead to placental growth hormone/lactogen deficiency. [provided by RefSeq].
McElholm, A.R., et al. Gastroenterology 139(1):204-212(2010)
de Jesus Romero-Prado, M.M., et al. Gene 452(1):7-15(2010)
Christiansen, M. Prenat. Diagn. 29(13):1249-1255(2009)
Zeck, W., et al. Pediatr. Res. 63(4):353-357(2008)
Mittal, P., et al. J. Matern. Fetal. Neonatal. Med. 20(9):651-659(2007)
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