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GNL2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q13823 |
| Other Accession | NP_037417.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 83655 Da |
| Antigen Region | 18-45 aa |
| Gene ID | 29889 |
|---|---|
| Other Names | Nucleolar GTP-binding protein 2, Autoantigen NGP-1, GNL2, NGP1 |
| Target/Specificity | This GNL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-45 amino acids from the N-terminal region of human GNL2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | GNL2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | GNL2 |
|---|---|
| Synonyms | NGP1 |
| Function | GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (PubMed:32669547). May promote cell proliferation possibly by increasing p53/TP53 protein levels, and consequently those of its downstream product CDKN1A/p21, and decreasing RPL23A protein levels (PubMed:26203195). |
| Cellular Location | Nucleus, nucleolus |
| Tissue Location | Widely expressed, with the highest expression level in testis. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
GNL2is a GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation (By similarity).
References
Olsen, J.V., et al. Cell 127(3):635-648(2006) Racevskis, J., et al. Cell Growth Differ. 7(2):271-280(1996)
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