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HOXD4 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - HOXD4 Antibody (C-term) AP16462b
    HOXD4 Antibody (C-term) (Cat. #AP16462b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the HOXD4 antibody detected the HOXD4 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P09016
Other Accession P10628, P17278, NP_055436.2
Reactivity Human
Predicted Chicken, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 27885 Da
Antigen Region 195-223 aa
Additional Information
Gene ID 3233
Other Names Homeobox protein Hox-D4, Homeobox protein HHOC13, Homeobox protein Hox-4B, Homeobox protein Hox-51, HOXD4, HOX4B
Target/Specificity This HOXD4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 195-223 amino acids from the C-terminal region of human HOXD4.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsHOXD4 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name HOXD4
Synonyms HOX4B
Function Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Cellular Location Nucleus.
Citations (0)
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Background

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in determining positional values in developing limb buds. Alternatively spliced variants have been described but their full length nature has not been determined.

References

Zhang, H., et al. Acta Pharmacol. Sin. 31(8):977-983(2010)
Ester, A.R., et al. Am. J. Med. Genet. A 149A (12), 2745-2752 (2009) :
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Tan, Y., et al. BMC Mol. Biol. 10, 12 (2009) :
van Scherpenzeel Thim, V., et al. Hum. Mutat. 25(4):384-395(2005)

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$ 182.50
$ 70.00
Cat# AP16462b
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