|Application ||WB, E|
|Calculated MW||23671 Da|
|Antigen Region||81-110 aa|
|Other Names||SAP domain-containing ribonucleoprotein, Cytokine-induced protein of 29 kDa, Nuclear protein Hcc-1, Proliferation-associated cytokine-inducible protein CIP29, SARNP, HCC1|
|Target/Specificity||This SARNP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 81-110 amino acids from the Central region of human SARNP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SARNP Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single- stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.|
|Cellular Location||Nucleus. Nucleus speckle.|
|Tissue Location||Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels are seen in hepatocellular carcinoma and pancreatic adenocarcinoma|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that is upregulated in response to various cytokines. The encoded protein may play a role in cell cycle progression. A translocation between this gene and the myeloid/lymphoid leukemia gene, resulting in expression of a chimeric protein, has been associated with acute myelomonocytic leukemia. Pseudogenes exist on chromosomes 7 and 8. Alternatively spliced transcript variants have been described. [provided by RefSeq].
Sugiura, T., et al. Exp. Cell Res. 313(4):782-790(2007)
Leaw, C.L., et al. Cell. Mol. Life Sci. 61(17):2264-2273(2004)
Hashii, Y., et al. Leukemia 18(9):1546-1548(2004)
Fukuda, S., et al. Biochem. Biophys. Res. Commun. 292(3):593-600(2002)
Choong, M.L., et al. FEBS Lett. 496 (2-3), 109-116 (2001) :
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