|Application ||WB, E|
|Calculated MW||101253 Da|
|Antigen Region||401-430 aa|
|Other Names||Centrobin, Centrosomal BRCA2-interacting protein, LYST-interacting protein 8, CNTROB, LIP8|
|Target/Specificity||This CNTROB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401-430 amino acids from the Central region of human CNTROB.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CNTROB Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for centriole duplication. Inhibition of centriole duplication leading to defects in cytokinesis.|
|Cellular Location||Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Centriole-associated, asymmetrically localizes to the daughter centriole|
|Tissue Location||Widely expressed (at protein level). Highly expressed in testis. Also expressed in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes|
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Provided below are standard protocols that you may find useful for product applications.
CNTROB is a centrosomal protein that interacts with BRCA2 (MIM 600185) and is required for centriole duplication and cytokinesis (Zou et al., 2005 [PubMed 16275750]).[supplied by OMIM].
Lee, J., et al. J. Biol. Chem. 285(33):25476-25484(2010)
Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
Jeffery, J.M., et al. Oncogene 29(18):2649-2658(2010)
Song, L., et al. Cell. Signal. 22(5):857-864(2010)
Jeong, Y., et al. J. Cell. Sci. 120 (PT 12), 2106-2116 (2007) :
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