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Mouse Bmpr1a Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | P36895 |
| Other Accession | Q78EA7, NP_033888.2 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 60063 Da |
| Antigen Region | 170-197 aa |
| Gene ID | 12166 |
|---|---|
| Other Names | Bone morphogenetic protein receptor type-1A, BMP type-1A receptor, BMPR-1A, Activin receptor-like kinase 3, ALK-3, BMP-2/BMP-4 receptor, Serine/threonine-protein kinase receptor R5, SKR5, CD292, Bmpr1a, Acvrlk3, Bmpr |
| Target/Specificity | This Mouse Bmpr1a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-197 amino acids from the Central region of mouse Bmpr1a. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Bmpr1a Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Bmpr1a |
|---|---|
| Synonyms | Acvrlk3, Bmpr |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction (PubMed:24098149). Mediates induction of adipogenesis by GDF6 (PubMed:23527555). May promote the expression of HAMP, potentially via its interaction with BMP2 (PubMed:31800957). |
| Cellular Location | Cell membrane {ECO:0000250|UniProtKB:P36898}; Single-pass type I membrane protein. Cell surface |
| Tissue Location | Widely expressed. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.
References
Drogat, B., et al. Blood 116(12):2141-2151(2010)
Leung, A.W., et al. Dev. Dyn. 239(9):2319-2329(2010)
Mira, H., et al. Cell Stem Cell 7(1):78-89(2010)
Libusova, L., et al. Development 137(14):2297-2305(2010)
Caronia, G., et al. J. Neurosci. 30(18):6291-6301(2010)
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