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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   Mouse Bmpr1a Antibody (Center)   

Mouse Bmpr1a Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - Mouse Bmpr1a Antibody (Center) AP16478c
    Mouse Bmpr1a Antibody (Center) (Cat. #AP16478c) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the Bmpr1a antibody detected the Bmpr1a protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P36895
Other Accession Q78EA7, NP_033888.2
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 60063 Da
Antigen Region 170-197 aa
Additional Information
Gene ID 12166
Other Names Bone morphogenetic protein receptor type-1A, BMP type-1A receptor, BMPR-1A, Activin receptor-like kinase 3, ALK-3, BMP-2/BMP-4 receptor, Serine/threonine-protein kinase receptor R5, SKR5, CD292, Bmpr1a, Acvrlk3, Bmpr
Target/Specificity This Mouse Bmpr1a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 170-197 amino acids from the Central region of mouse Bmpr1a.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsMouse Bmpr1a Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name Bmpr1a
Synonyms Acvrlk3, Bmpr
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction (PubMed:24098149). Mediates induction of adipogenesis by GDF6 (PubMed:23527555).
Cellular Location Membrane; Single-pass type I membrane protein
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Background

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP-2 and BMP-4.

References

Drogat, B., et al. Blood 116(12):2141-2151(2010)
Leung, A.W., et al. Dev. Dyn. 239(9):2319-2329(2010)
Mira, H., et al. Cell Stem Cell 7(1):78-89(2010)
Libusova, L., et al. Development 137(14):2297-2305(2010)
Caronia, G., et al. J. Neurosci. 30(18):6291-6301(2010)

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Cat# AP16478c
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(40 western blots)
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