|Application ||WB, E|
|Other Accession||Q9EQG9, Q6VVX2, Q9GKI7, NP_112729.1|
|Predicted||Bovine, Hamster, Mouse|
|Calculated MW||70835 Da|
|Antigen Region||95-124 aa|
|Other Names||Collagen type IV alpha-3-binding protein, Ceramide transfer protein, hCERT, Goodpasture antigen-binding protein, GPBP, START domain-containing protein 11, StARD11, StAR-related lipid transfer protein 11, COL4A3BP, CERT, STARD11|
|Target/Specificity||This COL4A3BP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-124 amino acids from the N-terminal region of human COL4A3BP.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||COL4A3BP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Shelters ceramides and diacylglycerol lipids inside its START domain and mediates the intracellular trafficking of ceramides and diacylglycerol lipids in a non-vesicular manner.|
|Cellular Location||Cytoplasm. Golgi apparatus. Endoplasmic reticulum Note=Preferentially localized to the Golgi apparatus|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene.
Miralem, T., et al. J. Biol. Chem. 285(17):12551-12558(2010)
Kudo, N., et al. J. Mol. Biol. 396(2):245-251(2010)
Lowe, J.K., et al. PLoS Genet. 5 (2), E1000365 (2009) :
Tomishige, N., et al. Mol. Biol. Cell 20(1):348-357(2009)
Asero, R., et al. Int. Arch. Allergy Immunol. 150(3):271-277(2009)
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