|Application ||WB, E|
|Calculated MW||39411 Da|
|Antigen Region||263-291 aa|
|Other Names||Visual system homeobox 2, Ceh-10 homeodomain-containing homolog, Homeobox protein CHX10, VSX2, CHX10, HOX10|
|Target/Specificity||This VSX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 263-291 amino acids from the C-terminal region of human VSX2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||VSX2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a significant role in the specification and morphogenesis of the sensory retina. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity).|
|Tissue Location||Abundantly expressed in retinal neuroblasts during eye development and in the inner nuclear layer of the adult retina. Within this layer, expression is stronger in the outer margin where bipolar cells predominate|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a homeobox protein originally described as a retina-specific transcription factor. Mutations in this gene are associated with microphthalmia, cataracts and iris abnormalities.
Gonzalez-Rodriguez, J., et al. Br J Ophthalmol 94(8):1100-1104(2010)
Iseri, S.U., et al. Hum. Genet. 128(1):51-60(2010)
Reichman, S., et al. Hum. Mol. Genet. 19(2):250-261(2010)
Nagel, S., et al. Mol. Cancer 9, 151 (2010) :
Zhang, X., et al. Mol. Vis. 15, 2911-2918 (2009) :
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