PGRMC2 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O15173 |
Other Accession | NP_006311.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 23818 Da |
Antigen Region | 192-221 aa |
Gene ID | 10424 |
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Other Names | Membrane-associated progesterone receptor component 2, Progesterone membrane-binding protein, Steroid receptor protein DG6, PGRMC2, DG6, PMBP |
Target/Specificity | This PGRMC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-221 amino acids from the C-terminal region of human PGRMC2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | PGRMC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | PGRMC2 (HGNC:16089) |
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Function | Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan (By similarity). May serve as a universal non-classical progesterone receptor in the uterus (Probable). Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus (By similarity). Plays a role in adipocyte function and systemic glucose homeostasis (PubMed:28111073). In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1 (By similarity). |
Cellular Location | Membrane; Single- pass membrane protein. Nucleus envelope. Endoplasmic reticulum. Secreted |
Tissue Location | Expressed by endometrial glands and stroma (at protein level) (PubMed:23793472). Detected in urine (at protein level) (PubMed:37453717). |
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Provided below are standard protocols that you may find useful for product applications.
Background
PGRMC2 is receptor for steroids (Potential).
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