|Application ||WB, E|
|Calculated MW||25038 Da|
|Antigen Region||137-165 aa|
|Other Names||Ras-related protein Rab-41, RAB41|
|Target/Specificity||This RAB41 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 137-165 amino acids from the C-terminal region of human RAB41.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RAB41 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for normal Golgi ribbon organization and ER-to- Golgi trafficking.|
|Cellular Location||Cytoplasm. Note=punctate localization concentrated in ruffled regions at the cell periphery|
|Tissue Location||Widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in liver|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. These proteins function as regulators of membrane trafficking. They cycle between inactive GDP-bound and activated GTP-bound states, which is controlled by GTP hydrolysis-activating proteins (GAPs). This family member can be activated by the GAP protein RN-Tre, and it is localized to the Golgi complex.
Haas, A.K., et al. Nat. Cell Biol. 7(9):887-893(2005)
Pereira-Leal, J.B., et al. J. Mol. Biol. 313(4):889-901(2001)
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