|Application ||WB, E|
|Other Accession||Q9R1V7, NP_003803.1|
|Calculated MW||91926 Da|
|Antigen Region||803-831 aa|
|Other Names||Disintegrin and metalloproteinase domain-containing protein 23, ADAM 23, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3, MDC-3, ADAM23, MDC3|
|Target/Specificity||This ADAM23 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 803-831 amino acids from the C-terminal region of human ADAM23.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADAM23 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
|Tissue Location||Highly expressed in the brain and weakly expressed in the heart. In the brain, expressed prominently in the amygdala, caudate nucleus, hypothalamus, thalamus, cerebral cortex and occipital pole.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain.
Pan, Q., et al. Biochem. Biophys. Res. Commun. 401(2):306-312(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Ferreira, M.A., et al. Allergy 64(11):1623-1628(2009)
Costa, M.D., et al. Neurosci. Lett. 461(1):16-20(2009)
Verbisck, N.V., et al. Cancer Res. 69(13):5546-5552(2009)
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