|Application ||WB, E|
|Calculated MW||45234 Da|
|Antigen Region||69-97 aa|
|Other Names||Actin-like protein 7B, Actin-like-7-beta, ACTL7B|
|Target/Specificity||This ACTL7B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 69-97 amino acids from the N-terminal region of human ACTL7B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ACTL7B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cytoplasm, cytoskeleton.|
|Tissue Location||Detected only in the testis and, to a lesser extent, in the prostate.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known.
Humphray, S.J., et al. Nature 429(6990):369-374(2004)
Hisano, M., et al. Nucleic Acids Res. 31(16):4797-4804(2003)
Chadwick, B.P., et al. Genomics 58(3):302-309(1999)
Schafer, D.A., et al. Annu. Rev. Cell Dev. Biol. 15, 341-363 (1999) :
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