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RFNG Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9Y644 |
| Other Accession | NP_002908.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 36424 Da |
| Antigen Region | 282-310 aa |
| Gene ID | 5986 |
|---|---|
| Other Names | Beta-1, 3-N-acetylglucosaminyltransferase radical fringe, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase, RFNG |
| Target/Specificity | This RFNG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 282-310 amino acids from the C-terminal region of human RFNG. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | RFNG Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | RFNG (HGNC:9974) |
|---|---|
| Function | Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by modifying O- fucose residues at specific EGF-like domains resulting in enhancement of NOTCH1 activation by DLL1 and JAG1. May be involved in limb formation and in neurogenesis. |
| Cellular Location | Golgi apparatus membrane; Single- pass type II membrane protein |
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Provided below are standard protocols that you may find useful for product applications.
Background
Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. May be involved in limb formation and in neurogenesis (By similarity).
References
Mikami, T., et al. Brain Res. Mol. Brain Res. 86 (1-2), 138-144 (2001) :
Moran, J.L., et al. Mamm. Genome 10(6):535-541(1999)
Johnston, S.H., et al. Development 124(11):2245-2254(1997)
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