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CCRL2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CCRL2 Antibody (Center) AP16519c
    CCRL2 Antibody (Center) (Cat. #AP16519c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the CCRL2 antibody detected the CCRL2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession O00421
Other Accession NP_003956.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 39513 Da
Antigen Region 206-234 aa
Additional Information
Gene ID 9034
Other Names C-C chemokine receptor-like 2, Chemokine receptor CCR11, Chemokine receptor X, Putative MCP-1 chemokine receptor, CCRL2, CCR11, CCR6, CKRX, CRAM, HCR
Target/Specificity This CCRL2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 206-234 amino acids from the Central region of human CCRL2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCCRL2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CCRL2
Synonyms CCR11, CCR6, CKRX, CRAM, HCR
Function Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T- cells (both CD4+ and CD8+), monocyte-derived iDCs, NK cells, and CD34+ progenitor cells. B-cells expressed isoform 1 but not isoform 2. Up-regulated on synovial neutrophils of rheumatoid arthritis patients.
Research Areas
Citations (0)

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This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.


Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Dubois, P.C., et al. Nat. Genet. 42(4):295-302(2010)
Leick, M., et al. Immunology 129(4):536-546(2010)
Segat, L., et al. Vaccine 28(10):2201-2206(2010)
Zabel, B.A., et al. J. Exp. Med. 205(10):2207-2220(2008)

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Cat# AP16519c
(40 western blots)
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