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NKIRAS2 Antibody (Center)Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
| Country | United States
Ordering Information
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| Catalog # | Size | Availability | Price | |
| AP16523c | 0.1 mg 400 ul | In Stock | $ 255.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
| AP16523c-ev20 | 20 ug 100 ul | In Stock | $ 95.00 | DISCONTINED INQUIRE CLICK INQUIRE Add to cart |
- Specification
- Citiations : 0
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NKIRAS2 Antibody (Center) - Product info | |
| Application | WB
|
| Primary Accession | Q9NYR9 |
| Other Accession | Q32NS2, Q9CR56, Q5ZJW6, NP_060065.2 |
| Reactivity | Human |
| Predicted | Chicken, Mouse, Xenopus |
| Concentration | 0.25 mg/ml |
| Isotype | Rabbit Ig |
| Calculated MW | 21508 Da |
NKIRAS2 Antibody (Center) - Additional info | |
| Gene ID 28511 | |
| Other Names NKIRAS2; KBRAS2; NF-kappa-B inhibitor-interacting Ras-like protein 2; I-kappa-B-interacting Ras-like protein 2 | |
| Target/Specificity This NKIRAS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 35-64 amino acids from the Central region of human NKIRAS2. | |
| Dilution WB~~1:100~500WB~~1:1000 | |
| Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. | |
| Storage Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. | |
| Precautions NKIRAS2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. | |
NKIRAS2 Antibody (Center) - Protein Information | |
| Name NKIRAS2 | |
| Synonyms KBRAS2 | |
| Function Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF- kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity) | |
| Cellular Location Cytoplasm (By similarity). | |
| Tissue Location Widely expressed. | |
NKIRAS2 Antibody (Center) - Related products
AP16523c: NKIRAS2 Antibody (Center)
RI13596: NKIRAS2 predesign siRNA
NKIRAS2 Antibody (Center) - Application data
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NKIRAS2 Antibody (Center) (Cat. #AP16523c) western blot analysis in U937 cell line lysates (35ug/lane).This demonstrates the NKIRAS2 antibody detected the NKIRAS2 protein (arrow).
NKIRAS2 Antibody (Center) - Research Areas
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BACKGROUND
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP-and GDP-bound forms block phosphorylation of NFKBIB (By similarity).
REFERENCES
Tago, K., et al. J. Biol. Chem. 285(40):30622-30633(2010) Dieguez-Gonzalez, R., et al. Ann. Rheum. Dis. 68(4):579-583(2009) Fenwick, C., et al. Science 287(5454):869-873(2000)
