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CCDC141 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q6ZP82 |
| Other Accession | NP_775919.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 175067 Da |
| Antigen Region | 1-30 aa |
| Gene ID | 285025 |
|---|---|
| Other Names | Coiled-coil domain-containing protein 141, Coiled-coil protein associated with myosin II and DISC1, CCDC141, CAMDI {ECO:0000303|PubMed:20956536} |
| Target/Specificity | This CCDC141 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human CCDC141. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CCDC141 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CCDC141 |
|---|---|
| Synonyms | CAMDI {ECO:0000303|PubMed:20956536} |
| Function | Plays a critical role in cortical radial and GnRH neurons migration during brain development. Regulates cortical radial migration by negatively controlling the activity of histone deacetylase 6 (HDAC6) and promotes centrosome maturation. CAMDI is required for dilation formation of cortical neurons during radial migration. Plays a critical role in learning and memory performance through regulation of AMPA- selective glutamate receptors (AMPARs) cell surface expression in competition with KIBRA. |
| Cellular Location | Cytoplasm {ECO:0000250|UniProtKB:E9Q8Q6}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250|UniProtKB:E9Q8Q6}. Note=Co-localized with DISC1 at/around the centrosome. Localizes to the centrosome, at least in part, in a DISC1-dependent manner. Accumulates and oscillates at the dilation in cortical neurons during migration. CAMDI protein level is stabilized at the G1 phase and destabilized at the G2 /M phase {ECO:0000250|UniProtKB:E9Q8Q6} |
Research Areas
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Ehret, G.B., et al. Eur. J. Hum. Genet. 17(12):1650-1657(2009)
Morris, J.A., et al. Hum. Mol. Genet. 12(13):1591-1608(2003)
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$ 365.00
$ 140.00
Cat# AP16548a
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