|Application ||WB, E|
|Calculated MW||93074 Da|
|Antigen Region||323-351 aa|
|Other Names||Taste receptor type 1 member 1, G-protein coupled receptor 70, TAS1R1, GPR70, T1R1, TR1|
|Target/Specificity||This TAS1R1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 323-351 amino acids from the Central region of human TAS1R1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TAS1R1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||GPR70, T1R1, TR1|
|Function||Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses.|
|Cellular Location||Cell membrane; Multi-pass membrane protein.|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a G protein-coupled receptor and is a component of the heterodimeric amino acid taste receptor T1R1+3. The T1R1+3 receptor responds to L-amino acids but not to D-enantiomers or other compounds. Most amino acids that are perceived as sweet activate T1R1+3, and this activation is strictly dependent on an intact T1R1+3 heterodimer. Multiple transcript variants encoding different isoforms have been found for this gene.
Fushan, A.A., et al. Chem. Senses 35(7):579-592(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
Prezeau, L., et al. Curr Opin Pharmacol 10(1):6-13(2010)
Chandrashekar, J., et al. Nature 444(7117):288-294(2006)
Xu, H., et al. Proc. Natl. Acad. Sci. U.S.A. 101(39):14258-14263(2004)
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