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AUP1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - AUP1 Antibody (C-term) AP16554b
    AUP1 Antibody (C-term) (Cat. #AP16554b) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the AUP1 antibody detected the AUP1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9Y679
Other Accession NP_853553.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 53028 Da
Antigen Region 440-468 aa
Additional Information
Gene ID 550
Other Names Ancient ubiquitous protein 1, AUP1
Target/Specificity This AUP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 440-468 amino acids from the C-terminal region of human AUP1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAUP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AUP1
Function May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.
Cellular Location Endoplasmic reticulum membrane; Single-pass type III membrane protein; Cytoplasmic side
Tissue Location Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain
Research Areas
Citations (0)

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This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.


Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Kato, A., et al. J. Biol. Chem. 277(32):28934-28941(2002)
Karpisheva, K.V., et al. Tsitologiia 44(9):846-851(2002)
Karpisheva, K.V., et al. Tsitologiia 44(9):839-845(2002)
Jang, W., et al. Genomics 36(2):366-368(1996)

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Cat# AP16554b
(40 western blots)
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