|Application ||WB, E|
|Calculated MW||53028 Da|
|Antigen Region||440-468 aa|
|Other Names||Ancient ubiquitous protein 1, AUP1|
|Target/Specificity||This AUP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 440-468 amino acids from the C-terminal region of human AUP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AUP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass type III membrane protein; Cytoplasmic side|
|Tissue Location||Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. The protein encoded by this gene has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.
Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :
Kato, A., et al. J. Biol. Chem. 277(32):28934-28941(2002)
Karpisheva, K.V., et al. Tsitologiia 44(9):846-851(2002)
Karpisheva, K.V., et al. Tsitologiia 44(9):839-845(2002)
Jang, W., et al. Genomics 36(2):366-368(1996)
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