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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   EDEM3 Antibody (C-term)   

EDEM3 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - EDEM3 Antibody (C-term) AP16556b
    EDEM3 Antibody (C-term) (Cat. #AP16556b) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the EDEM3 antibody detected the EDEM3 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BZQ6
Other Accession NP_079467.3
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 104664 Da
Antigen Region 774-802 aa
Additional Information
Gene ID 80267
Other Names ER degradation-enhancing alpha-mannosidase-like protein 3, Alpha-1, 2-mannosidase EDEM3, EDEM3, C1orf22
Target/Specificity This EDEM3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 774-802 amino acids from the C-terminal region of human EDEM3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsEDEM3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name EDEM3
Synonyms C1orf22
Function Involved in endoplasmic reticulum-associated degradation (ERAD). Accelerates the glycoprotein ERAD by proteasomes, by catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2 in the N-glycans. Seems to have alpha 1,2-mannosidase activity (By similarity).
Cellular Location Endoplasmic reticulum lumen {ECO:0000255|PROSITE-ProRule:PRU10138}
Research Areas
Citations (0)

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Quality control in the endoplasmic reticulum (ER) ensures that only properly folded proteins are retained in the cell through recognition and degradation of misfolded or unassembled proteins. EDEM3 belongs to a group of proteins that accelerate degradation of misfolded glycoproteins in the ER (Hirao et al., 2006 [PubMed 16431915]).


Hirao, K., et al. J. Biol. Chem. 281(14):9650-9658(2006)
Mast, S.W., et al. Glycobiology 15(4):421-436(2005)
Olivari, S., et al. J. Biol. Chem. 280(4):2424-2428(2005)
Sood, R., et al. Genomics 73(2):211-222(2001)

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Cat# AP16556b
(40 western blots)
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