|Application ||WB, E|
|Other Accession||Q9QXJ0, P38160, P38585, P38584, NP_714923.1|
|Predicted||Bovine, Mouse, Pig, Rat|
|Calculated MW||43212 Da|
|Antigen Region||232-263 aa|
|Other Names||Tubulin--tyrosine ligase, TTL, TTL|
|Target/Specificity||This TTL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-263 amino acids from the C-terminal region of human TTL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TTL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.|
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Provided below are standard protocols that you may find useful for product applications.
TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).
Dick, D.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :
Erck, C., et al. Cytogenet. Genome Res. 101(1):47-53(2003)
Mialhe, A., et al. Cancer Res. 61(13):5024-5027(2001)
Ersfeld, K., et al. J. Cell Biol. 120(3):725-732(1993)
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