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>   home   >   Products   >   Primary Antibodies   >   TTL Antibody (C-term)   

TTL Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - TTL Antibody (C-term) AP16574B
    TTL Antibody (C-term) (Cat. #AP16574b) western blot analysis in Ramos cell line lysates (35ug/lane).This demonstrates the TTL antibody detected the TTL protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q8NG68
Other Accession Q9QXJ0, P38160, P38585, P38584, NP_714923.1
Reactivity Human
Predicted Bovine, Mouse, Pig, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 43212 Da
Antigen Region 232-263 aa
Additional Information
Gene ID 150465
Other Names Tubulin--tyrosine ligase, TTL, TTL
Target/Specificity This TTL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-263 amino acids from the C-terminal region of human TTL.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTTL Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name TTL
Function Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin.
Citations (0)

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TTL is a cytosolic enzyme involved in the posttranslational modification of alpha-tubulin (see MIM 602529). Alpha-tubulin within assembled microtubules is detyrosinated over time at the C terminus. After microtubule disassembly, TTL restores the tyrosine residues and consequently participates in a cycle of tubulin detyrosination and tyrosination (Erck et al., 2003 [PubMed 14571137]).


Dick, D.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (6), 1179-1188 (2010) :
Erck, C., et al. Cytogenet. Genome Res. 101(1):47-53(2003)
Mialhe, A., et al. Cancer Res. 61(13):5024-5027(2001)
Ersfeld, K., et al. J. Cell Biol. 120(3):725-732(1993)

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Cat# AP16574B
(40 western blots)
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