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FNBP1L Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q5T0N5 |
| Other Accession | Q2HWF0, Q8K012, NP_001157945.1, NP_001020119.1 |
| Reactivity | Human, Mouse |
| Predicted | Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 70065 Da |
| Antigen Region | 349-377 aa |
| Gene ID | 54874 |
|---|---|
| Other Names | Formin-binding protein 1-like, Transducer of Cdc42-dependent actin assembly protein 1, Toca-1, FNBP1L, C1orf39, TOCA1 |
| Target/Specificity | This FNBP1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 349-377 amino acids from the Central region of human FNBP1L. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | FNBP1L Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | FNBP1L |
|---|---|
| Synonyms | C1orf39, TOCA1 |
| Function | Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Bu, W., et al. PLoS ONE 5 (8), E12153 (2010) :
Bu, W., et al. J. Biol. Chem. 284(17):11622-11636(2009)
Huett, A., et al. J. Immunol. 182(8):4917-4930(2009)
Leung, Y., et al. Cell Host Microbe 3(1):39-47(2008)
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