|Application ||WB, E|
|Other Accession||Q2HWF0, Q8K012, NP_001157945.1, NP_001020119.1|
|Calculated MW||70065 Da|
|Antigen Region||349-377 aa|
|Other Names||Formin-binding protein 1-like, Transducer of Cdc42-dependent actin assembly protein 1, Toca-1, FNBP1L, C1orf39, TOCA1|
|Target/Specificity||This FNBP1L antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 349-377 amino acids from the Central region of human FNBP1L.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FNBP1L Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle. Cell membrane; Peripheral membrane protein; Cytoplasmic side|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene binds to both CDC42 and N-WASP. This protein promotes CDC42-induced actin polymerization by activating the N-WASP-WIP complex and, therefore, is involved in a pathway that links cell surface signals to the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Bu, W., et al. PLoS ONE 5 (8), E12153 (2010) :
Bu, W., et al. J. Biol. Chem. 284(17):11622-11636(2009)
Huett, A., et al. J. Immunol. 182(8):4917-4930(2009)
Leung, Y., et al. Cell Host Microbe 3(1):39-47(2008)
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