|Application ||WB, E|
|Calculated MW||55049 Da|
|Antigen Region||52-81 aa|
|Other Names||Thymus-specific serine protease, 34--, Serine protease 16, PRSS16, TSSP|
|Target/Specificity||This PRSS16 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 52-81 amino acids from the N-terminal region of human PRSS16.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PRSS16 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Protease that may play a role in T-cell development.|
|Cellular Location||Cytoplasmic vesicle. Note=Vesicular, either lysosomal or endosomal|
|Tissue Location||Expressed predominantly in cortical thymic epithelial cells|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined.
Shi, J., et al. Nature 460(7256):753-757(2009)
Stefansson, H., et al. Nature 460(7256):744-747(2009)
Viken, M.K., et al. Genes Immun. 10(4):323-333(2009)
Lie, B.A., et al. Hum. Immunol. 68(7):592-598(2007)
Luther, C., et al. Genes Immun. 6(1):1-7(2005)
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