|Application ||WB, E|
|Other Accession||O35762, Q99MA9, NP_006159.2|
|Calculated MW||37849 Da|
|Antigen Region||6-1 aa|
|Other Names||Homeobox protein Nkx-61, Homeobox protein NK-6 homolog A, NKX6-1, NKX6A|
|Target/Specificity||This NKX6-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-314 amino acids from the C-terminal region of human NKX6-1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NKX6-1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity).|
|Tissue Location||Pancreatic beta cells.|
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Provided below are standard protocols that you may find useful for product applications.
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM].
Donelan, W., et al. J. Biol. Chem. 285(16):12181-12189(2010)
Zhu, S., et al. Dig. Dis. Sci. 54(5):996-1002(2009)
Schisler, J.C., et al. Mol. Cell. Biol. 28(10):3465-3476(2008)
Yokoi, N., et al. Diabetes 55(8):2379-2386(2006)
Hori, Y., et al. PLoS Med. 2 (4), E103 (2005) :
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