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>   home   >   Products   >   Primary Antibodies   >   Signal Transduction   >   NKX6-1 Antibody (C-term)   

NKX6-1 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - NKX6-1 Antibody (C-term) AP16589b
    NKX6-1 Antibody (C-term) (Cat. #AP16589b) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the NKX6-1 antibody detected the NKX6-1 protein (arrow).
  • WB - NKX6-1 Antibody (C-term) AP16589b
    NKX6-1 Antibody (C-term) (Cat. #AP16589b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the NKX6-1 antibody detected the NKX6-1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession P78426
Other Accession O35762, Q99MA9, NP_006159.2
Reactivity Human, Mouse
Predicted Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 37849 Da
Antigen Region 6-1 aa
Additional Information
Gene ID 4825
Other Names Homeobox protein Nkx-61, Homeobox protein NK-6 homolog A, NKX6-1, NKX6A
Target/Specificity This NKX6-1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 285-314 amino acids from the C-terminal region of human NKX6-1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsNKX6-1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name NKX6-1
Synonyms NKX6A
Function Transcription factor which binds to specific A/T-rich DNA sequences in the promoter regions of a number of genes. Involved in transcriptional regulation in islet beta cells. Binds to the insulin promoter and is involved in regulation of the insulin gene. Together with NKX2-2 and IRX3 acts to restrict the generation of motor neurons to the appropriate region of the neural tube. Belongs to the class II proteins of neuronal progenitor factors, which are induced by SHH signals (By similarity).
Cellular Location Nucleus.
Tissue Location Pancreatic beta cells.
Research Areas
Citations (0)

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In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM].


Donelan, W., et al. J. Biol. Chem. 285(16):12181-12189(2010)
Zhu, S., et al. Dig. Dis. Sci. 54(5):996-1002(2009)
Schisler, J.C., et al. Mol. Cell. Biol. 28(10):3465-3476(2008)
Yokoi, N., et al. Diabetes 55(8):2379-2386(2006)
Hori, Y., et al. PLoS Med. 2 (4), E103 (2005) :

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Cat# AP16589b
(40 western blots)
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