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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   KATNB1 Antibody (Center)   

KATNB1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - KATNB1 Antibody (Center) AP16597c
    KATNB1 Antibody (Center) (Cat. #AP16597c) western blot analysis in Y79 cell line lysates (35ug/lane).This demonstrates the KATNB1 antibody detected the KATNB1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9BVA0
Other Accession NP_005877.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 72334 Da
Antigen Region 331-359 aa
Additional Information
Gene ID 10300
Other Names Katanin p80 WD40 repeat-containing subunit B1 {ECO:0000255|HAMAP-Rule:MF_03022}, Katanin p80 subunit B1 {ECO:0000255|HAMAP-Rule:MF_03022}, p80 katanin {ECO:0000255|HAMAP-Rule:MF_03022}, KATNB1 {ECO:0000255|HAMAP-Rule:MF_03022}
Target/Specificity This KATNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 331-359 amino acids from the Central region of human KATNB1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsKATNB1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name KATNB1 {ECO:0000255|HAMAP-Rule:MF_03022}
Function Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.
Cellular Location Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton Note=Predominantly cytoplasmic. Localized to the interphase centrosome and mitotic spindle poles
Research Areas
Citations (0)

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Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.


Olson, J.E., et al. Breast Cancer Res. Treat. (2010) In press :
Cummings, C.M., et al. J. Biol. Chem. 284(17):11663-11675(2009)
Sudo, H., et al. Hum. Mol. Genet. 17(16):2524-2540(2008)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)

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$ 295.00
$ 99.00
Cat# AP16597c
(40 western blots)
Availability: In Stock
Bulk Size
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