|Application ||WB, E|
|Calculated MW||35278 Da|
|Antigen Region||280-309 aa|
|Other Names||Taste receptor type 2 member 31, T2R31, Taste receptor type 2 member 44, T2R44, Taste receptor type 2 member 53, T2R53, TAS2R31, TAS2R44|
|Target/Specificity||This TAS2R31 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 280-309 amino acids from the C-terminal region of human TAS2R31.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TAS2R31 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). Activated by the sulfonyl amide sweeteners saccharin and acesulfame K.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells|
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Provided below are standard protocols that you may find useful for product applications.
TAS2R44 belongs to the large TAS2R receptor family. TAS2Rs are expressed on the surface of taste receptor cells and mediate the perception of bitterness through a G protein-coupled second messenger pathway (Conte et al., 2002 [PubMed 12584440]). For further information on TAS2Rs, see MIM 604791.
Pronin, A.N., et al. Curr. Biol. 17(16):1403-1408(2007)
Fischer, A., et al. Mol. Biol. Evol. 22(3):432-436(2005)
Kuhn, C., et al. J. Neurosci. 24(45):10260-10265(2004)
Pronin, A.N., et al. Chem. Senses 29(7):583-593(2004)
Zhang, Y., et al. Cell 112(3):293-301(2003)
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