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SDCBP2 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SDCBP2 Antibody (N-term) AP16601a
    SDCBP2 Antibody (N-term) (Cat. #AP16601a) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the SDCBP2 antibody detected the SDCBP2 protein (arrow).
  • SPECIFICATION
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9H190
Other Accession NP_536737.3, NP_056500.2
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 31594 Da
Antigen Region 98-127 aa
Additional Information
Gene ID 27111
Other Names Syntenin-2, Syndecan-binding protein 2, SDCBP2, SITAC18
Target/Specificity This SDCBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-127 amino acids from the N-terminal region of human SDCBP2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSDCBP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SDCBP2 (HGNC:15756)
Synonyms SITAC18
Function Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997).
Cellular Location Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Cell membrane. Nucleus speckle. Note=Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments (PubMed:11102519). Colocalizes with TM4SF1 in the apical region of the cell (PubMed:11102519) Predominantly targeted to nuclear PIP2 pools. Shuttles between several subcellular compartments (PubMed:15961997). PIP2 plays an important role in the distribution of SDCBP2 (PubMed:23300061)
Tissue Location Preferentially expressed in cells of the digestive tract (PubMed:11102519). Low expression in skeletal muscle and kidney (PubMed:11102519). Detected in differentiated keratinocytes of normal and malignant epithelium (PubMed:22623796). In healthy skin, expression is localized in suprabasal epidermal layers (PubMed:22623796)
Research Areas
Citations (0)

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Background

Syntenin 2 binds to the cytoplasmic domains of the syndecans: it contains a tandem repeat of PDZ domains that reacts with the FYA (phe-tyr-ala) C-terminal amino acid sequence of the syndecans. Cells that overexpress the fusion protein show numerous cell surface extensions, suggesting that Syntenin 2 may have an effect on cytoskeleton-membrane organization. Therefore, Syntenin 2 may function as an adaptor that couples syndecans to cytoskeletal proteins or cytosolic downstream signal-effectors.

References

Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Koroll, M., et al. J. Biol. Chem. 276(14):10646-10654(2001)
Borrell-Pages, M., et al. Mol. Biol. Cell 11(12):4217-4225(2000)

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$ 295.00
$ 99.00
Cat# AP16601a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
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