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SDCBP2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9H190 |
| Other Accession | NP_536737.3, NP_056500.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 31594 Da |
| Antigen Region | 98-127 aa |
| Gene ID | 27111 |
|---|---|
| Other Names | Syntenin-2, Syndecan-binding protein 2, SDCBP2, SITAC18 |
| Target/Specificity | This SDCBP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 98-127 amino acids from the N-terminal region of human SDCBP2. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SDCBP2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SDCBP2 (HGNC:15756) |
|---|---|
| Synonyms | SITAC18 |
| Function | Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997). |
| Cellular Location | Cytoplasm. Nucleus, nucleolus Nucleus, nucleoplasm. Cell membrane. Nucleus speckle. Note=Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments (PubMed:11102519). Colocalizes with TM4SF1 in the apical region of the cell (PubMed:11102519). Predominantly targeted to nuclear PIP2 pools. Shuttles between several subcellular compartments (PubMed:15961997). PIP2 plays an important role in the distribution of SDCBP2 (PubMed:23300061). |
| Tissue Location | Preferentially expressed in cells of the digestive tract (PubMed:11102519). Low expression in skeletal muscle and kidney (PubMed:11102519). Detected in differentiated keratinocytes of normal and malignant epithelium (PubMed:22623796). In healthy skin, expression is localized in suprabasal epidermal layers (PubMed:22623796) |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Syntenin 2 binds to the cytoplasmic domains of the syndecans: it contains a tandem repeat of PDZ domains that reacts with the FYA (phe-tyr-ala) C-terminal amino acid sequence of the syndecans. Cells that overexpress the fusion protein show numerous cell surface extensions, suggesting that Syntenin 2 may have an effect on cytoskeleton-membrane organization. Therefore, Syntenin 2 may function as an adaptor that couples syndecans to cytoskeletal proteins or cytosolic downstream signal-effectors.
References
Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)
Deloukas, P., et al. Nature 414(6866):865-871(2001)
Koroll, M., et al. J. Biol. Chem. 276(14):10646-10654(2001)
Borrell-Pages, M., et al. Mol. Biol. Cell 11(12):4217-4225(2000)
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