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BEND3 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q5T5X7 |
| Other Accession | Q6PAL0, NP_001073919.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 94475 Da |
| Antigen Region | 629-657 aa |
| Gene ID | 57673 |
|---|---|
| Other Names | BEN domain-containing protein 3, BEND3, KIAA1553 |
| Target/Specificity | This BEND3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 629-657 amino acids from the C-terminal region of human BEND3. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BEND3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BEND3 |
|---|---|
| Synonyms | KIAA1553 |
| Function | Transcriptional repressor which associates with the NoRC (nucleolar remodeling complex) complex and plays a key role in repressing rDNA transcription. The sumoylated form modulates the stability of the NoRC complex component BAZ2A/TIP5 by controlling its USP21-mediated deubiquitination (PubMed:21914818, PubMed:26100909). Binds to unmethylated major satellite DNA and is involved in the recruitment of the Polycomb repressive complex 2 (PRC2) to major satellites (By similarity). Stimulates the ERCC6L translocase and ATPase activities (PubMed:28977671). |
| Cellular Location | Nucleus. Nucleus, nucleolus. Note=In the nucleus, observed in heterochromatic foci containing CBX1, CBX3, CBX5 and histone H3 trimethylated at 'Lys-9'. Released from chromatin during decondensation. Association with heterochromatin does not depend on sumoylation. |
| Tissue Location | Expressed at least in heart, kidney, liver, ovary and spleen, with highest levels in spleen and lowest in heart Expressed on the surface of T-cells. |
Citations (0)
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Application Protocols
Provided below are standard protocols that you may find useful for product applications.
References
Vertegaal, A.C., et al. Mol. Cell Proteomics 5(12):2298-2310(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Strausberg, R.L., et al. Proc. Natl. Acad. Sci. U.S.A. 99(26):16899-16903(2002)
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$ 365.00
$ 140.00
Cat# AP16612b
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