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SRP54 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - SRP54 Antibody (C-term) AP16615b
    SRP54 Antibody (C-term) (Cat. #AP16615b) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the SRP54 antibody detected the SRP54 protein (arrow).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P61011
Other Accession Q6AYB5, P14576, Q4R965, Q2T9U1, NP_003127.1, NP_001139754.1, Q7ZVN5
Reactivity Human
Predicted Bovine, Zebrafish, Monkey, Mouse, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 55705 Da
Antigen Region 346-374 aa
Additional Information
Gene ID 6729
Other Names Signal recognition particle 54 kDa protein, SRP54, SRP54
Target/Specificity This SRP54 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 346-374 amino acids from the C-terminal region of human SRP54.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsSRP54 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name SRP54 (HGNC:11301)
Function Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER) (PubMed:34020957). As part of the SRP complex, associates with the SRP receptor (SR) component SRPRA to target secretory proteins to the endoplasmic reticulum membrane (PubMed:34020957). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes (PubMed:34020957). Displays basal GTPase activity, and stimulates reciprocal GTPase activation of the SR subunit SRPRA (PubMed:28972538, PubMed:34020957). Forms a guanosine 5'-triphosphate (GTP)-dependent complex with the SR subunit SRPRA (PubMed:34020957). SR compaction and GTPase mediated rearrangement of SR drive SRP-mediated cotranslational protein translocation into the ER (PubMed:34020957). Requires the presence of SRP9/SRP14 and/or SRP19 to stably interact with RNA (By similarity). Plays a role in proliferation and differentiation of granulocytic cells, neutrophils migration capacity and exocrine pancreas development (PubMed:28972538, PubMed:29914977).
Cellular Location Nucleus speckle. Cytoplasm Endoplasmic reticulum
Research Areas
Citations (0)
citation

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Background

SRP54 binds to the signal sequence of presecretory protein when they emerge from the ribosomes and transfers them to TRAM (translocating chain-associating membrane protein).

References

Rose, J. Phd, et al. Mol. Med. (2010) In press :
Yoshida, M., et al. Mol. Pharmacol. 73(3):987-994(2008)
Sakashita, E., et al. Mol. Cell. Biol. 24(3):1174-1187(2004)
Kuglstatter, A., et al. Nat. Struct. Biol. 9(10):740-744(2002)
Yin, J., et al. RNA 7(10):1389-1396(2001)

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$ 182.50
$ 70.00
Cat# AP16615b
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