|Application ||WB, E|
|Other Accession||NP_001036046.1, NP_005692.1, NP_001036053.1|
|Calculated MW||41143 Da|
|Antigen Region||200-228 aa|
|Other Names||Snurportin-1, RNA U transporter 1, SNUPN, RNUT1, SPN1|
|Target/Specificity||This SNUPN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-228 amino acids from the Central region of human SNUPN.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SNUPN Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.|
|Cellular Location||Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling protein. Its nuclear import involves the nucleocytoplasmic transport receptor importin beta (PubMed:10209022, PubMed:12095920). It is re-exported to the cytoplasm by the XPO1- dependent nuclear export receptor pathway (PubMed:10209022)|
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Provided below are standard protocols that you may find useful for product applications.
The nuclear import of the spliceosomal snRNPs U1, U2, U4 and U5, is dependent on the presence of a complex nuclear localization signal. The latter is composed of the 5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U snRNA and the Sm core domain. The protein encoded by this gene interacts specifically with m3G-cap and functions as an snRNP-specific nuclear import receptor. Alternatively spliced transcript variants encoding the same protein have been identified for this gene.
Goette, M., et al. Biophys. J. 97(2):581-589(2009)
Monecke, T., et al. Science 324(5930):1087-1091(2009)
Ospina, J.K., et al. Mol. Biol. Cell 16(10):4660-4671(2005)
Stelzl, U., et al. Cell 122(6):957-968(2005)
Strasser, A., et al. EMBO J. 24(13):2235-2243(2005)
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