SYNGR2 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | O43760 |
Other Accession | NP_004701.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 24810 Da |
Antigen Region | 28-56 aa |
Gene ID | 9144 |
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Other Names | Synaptogyrin-2, Cellugyrin, SYNGR2 |
Target/Specificity | This SYNGR2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 28-56 amino acids from the N-terminal region of human SYNGR2. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SYNGR2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SYNGR2 (HGNC:11499) |
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Function | May play a role in regulated exocytosis. In neuronal cells, modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in the formation and/or the maturation of this vesicles. May also play a role in GLUT4 storage and transport to the plasma membrane. |
Cellular Location | Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:O54980}; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:O54980}; Multi-pass membrane protein. Note=Localizes to cytoplasmic vesicles associated with the recycling endosomes. {ECO:0000250|UniProtKB:O54980} |
Tissue Location | Ubiquitous; low expression in brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an integral membrane protein containing four transmembrane regions and a C-terminal cytoplasmic tail that is tyrosine phosphorylated. The exact function of this protein is unclear, but studies of a similar rat protein suggest that it may play a role in regulating membrane traffic in non-neuronal cells. The gene belongs to the synaptogyrin gene family. [provided by RefSeq].
References
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Kedra, D., et al. Hum. Genet. 103(2):131-141(1998)
Janz, R., et al. J. Biol. Chem. 273(5):2851-2857(1998)
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